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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Neuropharmacology. 2011 Dec 16;62(4):1858–1866. doi: 10.1016/j.neuropharm.2011.12.011

Figure 5.

Figure 5

ICSS does not alter locomotor sensitization to cocaine. Total locomotion over 30 minutes after injection of saline or cocaine (15 mg/kg i.p.) in sensitized mice at each time point is plotted as the mean distance traveled (in cm) ± SEM. White bars = Surgical and novelty control mice (Groups C and D, respectively; n = 20); black bars = ICSS mice (Groups A and B; n = 17). Letters indicate ICSS group tested on that day (see Figure 1). No differences were seen between sensitized ICSS and sensitized control mice (see Results). Tukey’s: * = P < 0.05 vs. Saline 1–3; † = P < 0.05 vs. Cocaine 1; ‡ = P < 0.05 vs. Cocaine 2. Inset: Total locomotion over 30 minutes on Saline 3 and the first presentation of cocaine in the locomotor apparatus (Cocaine 1 in Group A, Cocaine 2 in Group B, see Figure 1) to all ICSS mice. Sensitized ICSS mice, n = 17; Non-Sensitized ICSS mice, n = 7. * = P < 0.05 vs. Sensitized.