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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Neuropharmacology. 2011 Dec 16;62(4):1858–1866. doi: 10.1016/j.neuropharm.2011.12.011

TABLE 1.

Comparison of GluR1, GluR2 and CREB levels in non-ICSS control mice before (Group C; n = 6) and after (Groups C and D; n = 11) repeated intermittent cocaine administration, withdrawal and cocaine challenge (see Figure 1).

Ventral Tegmental Area (VTA)
GluR1 GluR2 CREB
Before Cocaine (Day 7) 1.01 ± 0.20 0.70 ± 0.18 2.74 ± 0.64
After Cocaine (Day 34) 1.69 ± 0.40 1.84 ± 0.33* 1.43 ± 0.13
Nucleus Accumbens (NAc)
GluR1 GluR2 CREB
Before Cocaine (Day 7) 1.89 ± 0.46 2.09 ± 0.42 1.21 ± 0.05
After Cocaine (Day 34) 0.93 ± 0.23* 0.49 ± 0.08* 0.55 ± 0.12*

All values are expressed as mean ratio of optical density of bands to β-Actin in the same sample ± SEM.

*

t-test for unmatched samples (2-tailed) P ≤ 0.05 vs. Day 7.

See Results for details.