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Recruitment Sensitivity to Chemokine-Receptor Kinetics. (A) Fractional receptor occupancy as predicted by Eq. 6.1 and (B) frequency of receptor occupancy as predicted by Eq. 6.2. The enclosed regions in (A) and (B) indicate physiological parameter space. (C) Predicted arrest distance as a function chemokine-receptor kinetics. (D) Mean arrest distance as a function of chemokine affinity and chemokine receptor expression. In all simulations [CC] = 103 μm−2.
