Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Eur Urol. 2011 Nov 7;61(3):471–477. doi: 10.1016/j.eururo.2011.10.047

Table 5.

Significant associations with aggressive prostate cancer risk in the Malmö Diet and Cancer Study

SNP Chr. Nearby genes of interest Clinical stage ≥T3 or evidence of metastasis at time of diagnosis (Definition 1; n = 239) WHO 3 or Gleason score ≥8 at time of diagnosis (Definition 2; n = 167) Clinical stage ≥T3, evidence of metastasis, WHO 3, or Gleason score ≥8 at time of diagnosis (Definition 3; n = 319)
OR (95% CI) p OR (95% CI) p OR (95% CI) p
rs10486567 7 JAZF1 0.80 (0.61–1.04) 0.091 0.66 (0.47–0.92) 0.013 0.75 (0.59–0.96) 0.021
rs1016343 8 MYC 1.30 (1.02–1.66) 0.035 1.34 (1.01–1.79) 0.043 1.28 (1.03–1.58) 0.024
rs10763588 10 MSMB; NCOA4 1.28 (1.04–1.59) 0.020 1.25 (0.97–1.62) 0.081 1.18 (0.98–1.42) 0.077
rs7098889 10 MSMB; NCOA4 1.29 (1.04–1.59) 0.018 1.22 (0.95–1.57) 0.12 1.17 (0.97–1.41) 0.092
rs10993994 10 MSMB; NCOA4 1.30 (1.05–1.62) 0.015 1.27 (0.98–1.64) 0.072 1.19 (0.99–1.44) 0.065
rs11228565 11 TPCN2; MYEOV 1.46 (1.14–1.88) 0.0029 1.29 (0.95–1.75) 0.096 1.38 (1.10–1.74) 0.0049
rs11649743 17 HNF1B 0.76 (0.59–1.00) 0.044 0.73 (0.52–1.01) 0.061 0.76 (0.60–0.96) 0.022
rs17632542 19 KLK3 0.57 (0.35–0.92) 0.021 1.07 (0.65–1.75) 0.8 0.74 (0.50–1.10) 0.13

SNP = single nucleotide polymorphism; Chr. = chromosome; WHO = World Health Organization; OR (95% CI): odds ratio and 95% confidence interval; p = p value for association test.