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. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Neuropharmacology. 2011 Dec 17;62(4):1874–1881. doi: 10.1016/j.neuropharm.2011.12.013

Concentrations of the pro-inflammatory cytokines from the cell culture supernatant (IL-6, IFN-γ and IL-17). Splenocytes were isolated from the spleens of EAE-induced mice that were treated with either PBS or PLP-BPI on days −11, −8, and −5. The pooled splenocytes (n = 3 mice) were stimulated in vitro with PLP_139–151 and supernatant was isolated 72 hours later for cytokine detection. Statistical significance values for the concentration of cytokines in PLP-BPI treated mice compared to that in the PBS group are as follows: A, p > 0.05, B, p < 0.0001, C, p < 0.05.

Concentrations of the pro-inflammatory cytokines from the cell culture supernatant (IL-6, IFN-γ and IL-17). Splenocytes were isolated from the spleens of EAE-induced mice that were treated with either PBS or PLP-BPI on days −11, −8, and −5. The pooled splenocytes (n = 3 mice) were stimulated in vitro with PLP_139–151 and supernatant was isolated 72 hours later for cytokine detection. Statistical significance values for the concentration of cytokines in PLP-BPI treated mice compared to that in the PBS group are as follows: A, p > 0.05, B, p < 0.0001, C, p < 0.05.