Fig. 3.

A false–negative result for CMC-001 enhanced MRI. In a T2-HASTE and b unenhanced T1-weighted images, the lesion (arrow) is hardly discernible from an adjacent liver vessel. In the T1 images after injection of gadobenate dimeglumine (c arterial, d portal venous and e hepatobiliary phases), the lesion has clearly lower signal intensity compared to the adjacent liver parenchyma. In f the T1-weighted image 3 h after ingestion of CMC-001, the lesion is difficult to detect as it is situated in a part of the liver with decreased uptake of CMC-001 due to decreased portal perfusion and/or hepatobiliary dysfunction