Table 1.
Final population pharmacokinetics
| Parameter | Estimate | RSE | Shrinkage (%)* |
|---|---|---|---|
| Basic pharmacokinetic parameter | |||
| CLMTX (l h−1) | 10.8 | 0.92 | |
| V1 (central MTX compartment) (l) | 34.0 | 5.4 | |
| V2 (peripheral MTX compartment) (l) | 6.3 | 1.6 | |
| 1.6 | |||
| Q (intercompartmental clearance) (l h−1) | 0.35 | 0.11 | |
| Interindividual variability | |||
| ω CLMTX (%) | 33.9 | 11.0 | 8.8 |
| ω V1 (%) | – | – | |
| ωV2 (%) | 35.8 | 19.3 | 16.1 |
| ω Q (%) | – | – | |
| Interoccasion variability Residual variability (%) | 13.3 | 4.3 | |
| σ MTX (%) | 31.8 | 21.8 | 12.7 |
*
Parameter shrinkage to the mean, defined as parameter standard deviation divided by ω. ω, interindividual variability; σ, residual variability; CLMTX, clearance of methotrexate; RSE, relative standard error.