Table 2.

MTX dosing algorithm based on 24 h MTX plasma concentrations

MTX AUC (µmol l−1 h)	C24 MTX (µmol l−1)	Dose adaptation (%)	Proportion of patients (%)
C3	C4
<600	<0.5	+75	4.6
600–700	0.5–1.0	+55	17.5
700–800	1.0–2.0	+35	24.0
800–900	2.0–3.0	+15	14.9
900–1.000	3.0–4.0	+5	10.4
1.000–1.100	4.0–5.0	unchanged	7.5
1.100–1.200	5.0–7.0	–5	10.1
1.200–1.300	7.0–9.0	–15	6.1
1.300–1.400	9.0–12.0	–25	3.7
>1.400	>12.0	–35	1.2

C, cycle; AUC, area under the concentration–time curve.