Table 3.
Associations between individual CYP enzymes in transformed CLint
| Kendall's tau-b coefficient of CYP enzyme | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1A2 | 2A6 | 2B6 | 2C8 | 2C9 | 2C19 | 2D6 | 2E1 | 3A-m | 3A-t |
| 1A2 | 0.22 | 0.07 | 0.24 | 0.08 | 0.25 | 0.21 | 0.03 | −0.09 | 0.21 |
| (0.21) | (0.20) | (0.20) | (0.09) | (0.38*) | (0.02) | (0.02) | (0.27*) | (0.23) | |
| 2A6 | 0.19 | 0.30* | 0.08 | −0.06 | 0.27* | 0.27* | 0.03 | 0.03 | |
| (0.34*) | (0.30*) | (0.09) | (0.27*) | (0.26*) | (0.10) | (0.25) | (0.39*) | ||
| 2B6 | 0.44* | 0.02 | −0.26* | 0.17 | 0.28* | −0.13 | 0.30* | ||
| (0.52*) | (0.02) | (−0.01) | (0.32*) | (0.33*) | (0.17) | (0.36*) | |||
| 2C8 | 0.01 | −0.26* | 0.12 | 0.30* | −0.26* | 0.14 | |||
| (0.30*) | (0.05) | (0.46*) | (0.45*) | (0.06) | (0.31*) | ||||
| 2C9 | −0.04 | 0.38* | −0.11 | 0.42* | 0.17 | ||||
| (0.10) | (0.27*) | (0.16) | (0.02) | (−0.10) | |||||
| 2C19 | −0.12 | −0.22 | −0.04 | 0.15 | |||||
| (0.02) | (−0.20) | (0.20) | (0.25*) | ||||||
| 2D6 | −0.01 | 0.15 | 0.04 | ||||||
| (0.27*) | (−0.07) | (0.14) | |||||||
| 2E1 | −0.16 | 0.13 | |||||||
| (0.02) | (0.07) | ||||||||
| 3A-m | −0.01 | ||||||||
| (0.32*) | |||||||||
CLint values were transformed by dividing by the group median for calculation of Kendall's tau-b coefficients that were used to measure the associations. In addition to the data for the Chinese samples, the data for the Caucasian samples were also exhibited in parentheses. ‘3A-m’ and ‘3A-t’ represent the CYP3A towards midazolam metabolism and testosterone metabolism, respectively.
*
Correlations were statistically significant with a P value of <0.05 (two-tailed).