Table 1.

Difference between baseline and 1 year measurements of lipid fractions and CRP by rs4149056 genotype

		Genotypes
	TT/TC/CC n	TT Mean (SE)	TC Mean (SE)	CC Mean (SE)	Overall P value	CC vs. TC + TT P value
Total cholesterol (mmol l−1)	449/164/13
Baseline		7.10 (0.042)	7.08 (0.045)	7.21 (0.070)	0.088	0.040‡
1 year		5.88 (0.189)	5.90 (0.201)	6.13 (0.322)	0.65	0.36
Difference†		−1.18 (0.189)	−1.16 (0.201)	−0.96 (0.323)	0.71	0.42
% change†		−16.6%(2.68)	−16.3% (2.86)	−13.1% (4.58)	0.62	0.35
HDL cholesterol (mmol l−1)	449/164/13
Baseline		1.15 (0.045)	1.15 (0.048)	1.13 (0.075)	0.93	0.82
1 year		1.23 (0.056)	1.24 (0.060)	1.21 (0.095)	0.92	0.74
Difference†		0.09 (0.034)	0.09 (0.037)	0.07 (0.059)	0.93	0.77
% change†		7.16% (2.98)	7.70% (3.17)	5.05% (5.07)	0.80	0.59
LDL cholesterol (mmol l−1)	449/164/13
Baseline		5.06 (0.090)	5.06 (0.096)	4.91 (0.150)	0.45	0.21
1 year		3.93 (0.175)	3.93 (0.187)	4.04 (0.299)	0.89	0.64
Difference†		−1.11 (0.167)	−1.11 (0.178)	−0.92 (0.285)	0.73	0.43
% change†		−22.2% (3.38)	−22.2% (3.61)	−17.7% (5.77)	0.62	0.33
Triglycerides (mmol l−1)*	449/164/13
Baseline		1.88 (1.074)	1.99 (1.078)	1.62 (1.126)	0.048‡	0.085
1 year		1.73 (1.094)	1.75 (1.100)	1.60 (1.164)	0.77	0.51
Ratio†		0.94 (1.074)	0.91 (1.079)	0.95 (1.130)	0.68	0.87
CRP (mg l−1)*	398/139/11
Baseline		2.08 (1.224)	2.06 (1.241)	1.93 (1.413)	0.97	0.80
1 year		1.92 (1.249)	2.13 (1.264)	2.28 (1.439)	0.49	0.62
Ratio†		0.91 (1.186)	1.01 (1.198)	1.25 (1.332)	0.15	0.21

Results are presented as adjusted mean (SE) except

^*which are adjusted geometric mean (SE).

^†In addition adjusted for baseline level. n indicates number of participants for whom baseline and 1 year data were available.

^‡Similar differences in baseline total cholesterol and triglycerides were not seen in placebo treated participants and are probably due to chance.