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Levels of Gb3 and lyso-Gb3 in Fabry mouse organs. Fabry mice were repeatedly injected with yr-hGLA or agalsidase alfa (1.0 mg/kg body weight) separately every day for 4 d and sacrificed 24 h after the last injection. Then, the levels of Gb3 (left) and lyso-Gb3 (right) in the organs were determined. ■, Wild-type mice; □, Fabry mice;
, Fabry mice treated with yr-hGLA;
, Fabry mice treated with agalsidase alfa. Error bars represent mean ± SD (n = 3). *P < 0.05. ND, not detected.
