Figure 2.

Diverse roles of Notch signaling in regulating angiogenic ocular angiogenesis. Ocular vasculature formation is a finely ordered vascular system that relies on physiological angiogenesis. Pathological angiogenesis, on the other hand, results in a various angiogenesis related ocular diseases such as retinal neovascularization (RNV) and CNV. Notch signaling participates in vasculature formation and angiogenic ocular diseases by regulating vascular quiescence through p21 and Wnt signaling (1), angiogenic sprouting through tip formation and guidance (2), vessels maturation through EC-pericyte communication (3), EPC mobilization and function (4) and EC functions (5). Therefore, intervention of Notch signaling in each step of angiogenesis might have therapeutic potentials.