Table 3.

Summary of various technologies that utilize geometric factors in drug delivery.

Technology	Design	Factors Affecting Drug Release	Type of Drug Release That May Be Achieved
Geomatrix®	Triple/bilayered tablet.	Type of polymer used, thickness of layers.	Zero-order kinetics
Smartrix®	Triple-layered tablet with core layer having a specific shape different to that of the outer layers.	Shape of core layer.	According to shape of core, zero-order kinetics
Procise®	Uniformly dispersed drug core containing a hole.	Geometry of core	According to geometry of core, zero-order kinetics
Dome Matrix®/“Release modules assemblage”	Elementary module containing a concave base side and a convex base side. Various arrangements of modules to form different structures	Arrangement of modules, type of polymeric material used.	Various according to arrangement of modules e.g., Concave base attached to concave base.
Core-in-cup devices	Disc-shaped core compression coated on one surface and circumference to form a cup around it.	Type of polymer, dimensions of core and cup.	Zero-order kinetics
Doughnut-shaped tablets	Single/triple-layered tablets with a central hole/holes	Size and number of holes, type of polymer used Zero-order kinetics Sodas® Multilayer tablet Type of polymer used, thickness of layers. Shape of core layer	Pursatile drug release
VersaTab®	Bilayered tablet	Core drug, polymer layers	Immediate release and controlled release
GeolockTM	Triple layered tablet	Polymer layers, single or combination of drugs in the inner core	Immediate or modified release