Figure 8.

TEA-sensitive potassium channels control the repolarizing phase of the action potential. A–C, Left, Confocal z-projection of a voltage-sensitive dye-filled interneuron. Colored box refers to the dendritic region of interest during imaging. Right, examples of action potential waveform recorded electrically at the soma or optically in the dendrite during control, drug, and wash conditions. Concentrations: TEA 1 mm, IBTX 100 nM, α-DTX 100 nm. D, Summary of drug effects on the action potential full-width at half-height expressed as a percentage of control (average ± SEM). Black bars are somatic waveform changes recorded electrically (TEA: n = 6; IBTX: n = 5; α-DTX: n = 6 cells). Gray bars are dendritic waveform changes recorded optically (TEA: n = 4; IBTX: n = 4; α-DTX n = 5 cells).