Skip to main content
. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Inflamm Regen. 2011 Mar;31(2):157–166. doi: 10.2492/inflammregen.31.157

Fig. 2. Regulation of mPGES-1 expression in rheumatoid synovial fibroblasts and chondrocytes.

Fig. 2

COX-2 and mPGES-1 are coordinately induced in cultured synovial fibroblasts and chondrocytes by stimulation of pro-inflammatory cytokines such as interleukin1β (IL-1β). Abundant PGE2 production at the inflammation sites of rheumatoid arthritis (RA) is caused by the coordinated up-regulation of mPGES-1 and COX-2. PGE2 further enhances mPGES-1 expression associated with increase of cyclic AMP (cAMP) via the EP2 and EP4 receptors. The positive feedback regulation of mPGES-1 expression by PGE2 may play an important role in the vicious circle of inflammation associated with RA 11-14.