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Metastatic human and murine lymph nodes exhibiting a spectrum of involvement. a Human metastatic breast cancer with focal lymph node involvement (arrow) at low (left) and high power (right) showing preservation of lymph node architecture. b Metastatic melanoma replacing a regional lymph node and obscuring architectural features at low (left) and high (right) powers. c Murine lymph node replaced by tumor, H&E (left), immunohistochemistry (right)
