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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Immunity. 2008 Dec 19;29(6):947–957. doi: 10.1016/j.immuni.2008.11.003

Figure 4. Differential expression of IL-22 in activated NK cells by IL-23 or IL-12.

Figure 4

NK1.1+ TCRβ− CD27low (CD27low) or NK1.1+ TCRβ− CD27high (CD27high) NK cells were sorted from the spleen and lymph nodes of C57BL/6 mice. Cells were stimulated in vitro with IL-15 and the indicated cytokines. 18 hrs post-stimulation, IL-22 and IFNγ mRNA and protein expression was analyzed by (A) real-time RT-PCR or (B) ELISA of the supernatants, respectively. Experiment was performed three times with similar results.