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. 2012 Jan 19;8(1):e1002352. doi: 10.1371/journal.pcbi.1002352

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Achcar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — (A) Percentage of models that reach steady-state within 300 minutes as a function of phosphoglycerate mutase (B) Percentage of models that reach steady-state within 300 minutes as a function of pyruvate transport . The red line is the distribution of the parameter as it is usually sampled. The black line is the fixed-parameter value. A model which has a value for one of these two parameters smaller than the mean will easily fail to reach steady-state, whatever the other parameter values and despite these values still being close to their mean. This reveals fragilities in the model.

(A) Percentage of models that reach steady-state within 300 minutes as a function of phosphoglycerate mutase (B) Percentage of models that reach steady-state within 300 minutes as a function of pyruvate transport . The red line is the distribution of the parameter as it is usually sampled. The black line is the fixed-parameter value. A model which has a value for one of these two parameters smaller than the mean will easily fail to reach steady-state, whatever the other parameter values and despite these values still being close to their mean. This reveals fragilities in the model.