Cellular polyamine concentrations of IEC-6 exposed to NSAIDs. Panel A: Polyamine content of IEC-6 cells treated with DFMO (5 mM) in the absence and presence of exogenous spermadine (SPD, 5 μM). Panel B: IEC-6 treated with indomethacin (Indo, 100 μM), phenylbutazone (PBZ, 100 μM), SC-560 (1 μM) and NS-398 (100 μM). Cellular polyamine concentrations were measured by LC-MS at 78 h post-treatment (n= 3). Asterisks indicate significant difference from control (p < 0.05).