. Author manuscript; available in PMC: 2012 Feb 1.

Published in final edited form as: Biochem Pharmacol. 2007 Apr 4;74(1):74–85. doi: 10.1016/j.bcp.2007.03.030

Table 1.

INHIBITOR	IC50 (μM) Cox-1	IC50 (μM) Cox-2	COX SELECTIVITY^*	ULCEROGENIC POTENTIAL
Indomethacin (human)	0.19	0.44	0.4	+++
Indomethacin (horse)	0.036	0.43	0.08	+++
SC-560 (human)	0.005	1.4	0.003	0
NS-398 (rat)	125	5.6	22	(+) slows ulcer healing
Phenylbutazone (horse)	6.15	3.79	1.6	+++

Ratio of IC50 for COX-1 to IC50 for COX-2 (positively correlated with COX-2 selectivity such that a ratio < 1 indicates COX-1 selectivity and a ratio > 1 indicates COX-2 selectivity). Based on references [33–36]