Table 1.
Comparison of clinical data between patients with and without TMA
| Parameter | TMA | No TMA | P Value |
|---|---|---|---|
| Number of patients | 68 | 60 | |
| Age (years) | 39.7 (29–49) | 36.2 (26–44) | >0.10 |
| Male | 49 of 68 = 72.1% | 41 of 60 = 68.3% | >0.10 |
| Initial systolic BP (mmHg) | 161 (135–177) | 130 (120–140) | 0.00 |
| Initial diastolic BP (mmHg) | 94 (80–107) | 77 (67–85) | 0.000002 |
| Percentage hypertensive | 48 of 68 = 70.6% | 14 of 60 = 23.3% | 0.00 |
| Percentage MHT | 18 of 68 = 26% | 0 of 60 = 0 | 0.00 |
| Final systolic BP (mmHg) | 131 (120–144) | 122 (110–130) | 0.004 |
| Final diastolic BP (mmHg) | 81 (72–87) | 74 (69–80) | >0.10a |
| Number of antihypertensive agents | 2.8 (2–4) | 1.4 (1–2) | 0.00 |
| Proteinuria Dx (g/day) | 3.37 (1.2–4.0) | 1.33 (0.40–1.85) | 0.00 |
| Macroscopic hematuria | 11 of 59 = 18.6% | 22 of 46 = 47.8% | 0.0014 |
| Serum albumin (g/L) | 34.6 (30–39) | 39.8 (36–43) | 0.0001 |
| Initial SCr (μmol/L) | 368 (140–412) | 123 (80–130) | 0.00 |
| eGFR (ml/min per 1.73 m2) | 34 (14–50) | 73 (51–90) | 0.00 |
| Final SCr (μmol/L) | 340 (123–569) | 156 (81–119) | 0.00 |
| Final eGFR (ml/min per 1.73 m2) | 23 (0–49) | 69 (50–96) | 0.00 |
| Bad outcomeb | 34 of 68 = 50.0% | 6 of 53 = 11.3% | 0.00 |
| RRT | 30 of 68 = 44.1% | 5 of 53 = 9.4% | 0.00 |
| Laboratory evidence of TMA | 8 of 65 = 12.3% | 0 of 55 = 0 | 0.01 |
| Family history | 5 of 53 = 9.4% | 7 of 39 = 17.9% | >0.10 |
Values expressed as mean (25th to 75th percentile) or percentages. P values calculated by Mann–Whitney U test or Fisher’s exact test as appropriate. BP, blood pressure; Dx, diagnosis.
aValue of >0.10 after Holm–Bonferroni correction to minimize type 1 error (α=0.05).
bBad outcome defined as doubling of initial SCr or need for dialysis.