Table 2.
Clinical and morphologic differences between patients with normotension, moderate hypertension, and MHT at the time of diagnosis
| Parameter | Normotensive, No Antihypertensors | P Value | Normotensive on Antihypertensors | P Value | Hypertension | P Value | MHT | P Value (Versus Normotensive without Treatment) |
|---|---|---|---|---|---|---|---|---|
| Number of patients | 19 | 44 | 47 | 18 | ||||
| Systolic BP Dx (mmHg) | 119 (114–127) | 0.01 | 126 (120–133) | 0.00 | 162 (150–170) | 0.001 | 193 (164–220) | 0.00 |
| Diastolic BP Dx (mmHg) | 72 (62–80) | >0.10 | 73 (66–80) | 0.00 | 95 (88–100) | 0.002 | 111 (97–125) | 0.000001 |
| SCr Dx (μmol/L) | 113 (79–141) | >0.10 | 173 (81–163) | 0.001 | 215 (126–136) | 0.0001 | 739 (248–1316) | 0.000003 |
| eGFR Dx (ml/min per 1.73 m2) | 77 (68–89) | >0.10 | 63 (44–89) | 0.002 | 44.3 (26.4–55.6) | 0.00001 | 15.8 (4.3–20.0) | 0.000001 |
| Proteinuria Dx (g/day) | 1.01 (0.11–1.90) | >0.10 | 1.42 (0.66–2.00) | 0.0004 | 3.34 (1.10–4.05) | >0.10 | 4.21 (2.00–6.40) | 0.00004 |
| Laboratory evidence of TMA | 0 of 16 = 0 | >0.10 | 1 of 41 = 2.4% | >0.10 | 2 of 45 = 4.5% | 0.01 | 5 of 18 = 27.7% | 0.03 |
| TMA | ||||||||
| arterial | ||||||||
| acute, with fibrin | 0 of 19 = 0 | >0.10 | 2 of 44 = 4.5% | >0.10 | 6 of 47 = 12.8% | >0.10 | 6 of 18 = 33.3% | 0.001 |
| organized | 0 of 19 = 0 | >0.10 | 3 of 44 = 6.8% | 0.03 | 11 of 47 = 23.4% | >0.10 | 6 of 18 = 33.3% | 0.001 |
| arteriolar | ||||||||
| acute, with fibrin | 1 of 19 = 5.2% | >0.10 | 5 of 44 = 11.3% | >0.10 | 9 of 47 = 19.1% | >0.10 | 4 of 18 = 22.2% | >0.10 |
| organized | 3 of 19 = 15.8% | >0.10 | 13 of 44 = 29.5% | 0.02 | 25 of 47 = 53.2% | >0.10 | 11 of 18 = 61.1% | 0.005 |
| Any TMA (acute or organized, arterial or arteriolar) | 3 of 19 = 15.8% | 0.07 | 17 of 44 = 38.6% | 0.01 | 31 of 47 = 65.9% | 0.004 | 18 of 18 = 100% | 0.00 |
| Bad outcomea | 1 of 19 = 5.2% | >0.10 | 8 of 44 = 18.2% | 0.04 | 17 of 45 = 37.8% | 0.002 | 14 of 17 = 82.3% | 0.00 |
| RRT | 0 of 19 = 0 | 0.05 | 8 of 44 = 18.2% | >0.10 | 13 of 45 = 28.9% | 0.0002 | 14 of 17 = 82.3% | 0.00 |
| Immediate RRTb | 0 of 19 = 0 | >0.10 | 4 of 44 = 9.1% | >0.10 | 3 of 45 = 6.7% | 0.0002 | 9 of 17 = 57.9% | 0.0003 |
Values expressed as mean (25th to 75th percentile) or percentages. P values calculated by Mann–Whitney U test or Fisher’s exact test as appropriate. BP, blood pressure; Dx, diagnosis.
aBad outcome is defined as doubling of SCr or need for dialysis.
bImmediate RRT is defined by RRT initiation <3 months after biopsy.