Table 4.
Univariate analysis of clinical and vascular factors associated with bad outcome
| Bad Outcomea | Preserved Renal Function | P Value | |
|---|---|---|---|
| Number of patients | 40 | 81 | |
| Clinical parameters | |||
| systolic Dx (mmHg) | 167 (140–197) | 139 (120–150) | 0.000002 |
| diastolic Dx (mmHg) | 97 (80–115) | 82 (70–90) | 0.0002 |
| HBP Dx | 37 of 40 = 92.5% | 55 of 81 = 67.9% | 0.003 |
| systolic BP, end | 136 (124–154) | 123 (111–130) | 0.000001 |
| MHT | 14 of 40 = 35% | 3 of 81 = 3.7% | 0.00 |
| proteinuria Dx (g/day) | 3.99 (1.81–5.30) | 1.81 (0.49–2.52) | 0.000001 |
| proteinuria, end (g/day) | 3.32 (1.80–4.92) | 0.94 (0.10–1.07) | 0.0001 |
| serum albumin (g/L) | 32.6±1.08 | 39.1±0.64 | 0.000004 |
| SCr Dx (μmol/L) | 537 (190–759) | 125 (89–161) | 0.00 |
| eGFR Dx (ml/min per 1.73 m2) | 22 (6–34) | 66 (44–83) | 0.00 |
| laboratory evidence of TMA | 8 of 38 = 21.1% | 0 of 78 = 0 | 0.00 |
| Vascular parameters (arbitrary units) | |||
| arteriosclerosis, global | 2.34 (2–3) | 1.72 (1–2) | 0.01 |
| arterial intimal sclerosis | 1.59 (1–3) | 0.99 (0–2) | 0.01 |
| arterial S/M hypertrophy | 0.99 (0–2) | 0.52 (0–1) | 0.002 |
| arterial hyalin deposits | 0.42 (0–1) | 0.24 (0–0) | 0.06 |
| arteriolar lumen caliber | 2.04 (1.5–2.0) | 2.60 (2–3) | 0.000001 |
| arteriolar S/M hypertrophy | 0.67 (0–1) | 0.38 (0–1) | 0.003 |
| arteriolar hyalin deposits | 0.82 (0–1) | 0.81 (0–1.5) | >0.10 |
| TMA by vessel size | |||
| arterial fibrinoid TMA | 11 of 40 = 27.5% | 4 of 81 = 4.9% | 0.0004 |
| arterial organized TMA | 10 of 40 = 25% | 11 of 81 = 13.6% | >0.10 |
| arteriolar fibrinoid TMA | 10 of 40 = 25% | 9 of 81 = 11.1% | 0.05 |
| arteriolar organized TMA | 25 of 40 = 62.5% | 26 of 81 = 32.1% | 0.0014 |
| TMA: all vessels | |||
| fibrinoid TMA | 22 of 40 = 55% | 19 of 81 = 23.5% | 0.001 |
| organized TMA | 29 of 40 = 72.5% | 28 of 81 = 34.6% | 0.0001 |
| any TMA | 34 of 40 = 85% | 34 of 81 = 42% | 0.00 |
Values expressed as mean (25th to 75th percentile) or percentages. P values calculated by Mann–Whitney U test or Fisher’s exact test as appropriate. Dx, diagnosis, HBP, high BP; MHT, malignant hypertension; S/M, smooth muscle.
a
Bad outcome defined as doubling of SCr or need for dialysis.