Table 5.

Analysis of rate of decline of renal function and outcome

Parameter	Rateof Decline of eGFR (ml/min per 1.73 m2 per year)					Factors Associated with Bad Outcomea
	Multiple Linear Regression F(9,82)=5.2877, P<0.00001, R2=0.3672					Cox Proportional Hazards Modeling χ2=111.34, df=9, P=0.00000
	β	SEM β	t Value	P Value		β	SEM β	t Value	P Value
Mesangial hypercellularity	0.0668	0.1082	0.6174	0.54		0.6969	0.4064	1.7194	0.09
Segmental glomerulosclerosis	0.2154	0.1006	2.143	0.04		−0.7873	0.6667	−1.1809	0.24
Endocapillary proliferation	0.1502	0.1130	1.3298	0.19		−0.0368	0.4029	−0.0914	0.93
Percentage tubular atrophy/interstitial fibrosis	0.2926	0.1484	1.9716	0.05		0.0033	0.0103	0.3217	0.74
Proteinuria Dx	0.0957	0.1124	0.0964	0.37		−0.0183	0.0561	−0.3263	0.74
eGFR Dx	0.4052	0.1514	2.576	0.01		−0.0923	0.0209	−4.4223	0.00001
Mean arterial pressure Dx	0.0108	0.1119	0.8515	0.92		0.0003	0.0085	0.0362	0.97
Morphologic TMA	0.0817	0.1175	0.6958	0.49		0.6394	0.5488	1.1651	0.24
Laboratory evidence of TMA	0.3367	0.0959	3.5128	0.001		1.3334	0.6069	2.1990	0.03

Bold designates P<0.05. Dx, diagnosis.

^aBad outcome defined as doubling serum creatinine or ESRD.