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Renal cortical expression of TLR4 in diabetic and nondiabetic TLR4+/+ mice. (A) TLR4 mRNA expression, determined by real-time PCR, in renal cortex 12 weeks after STZ induction. (B) Representative photomicrograph of renal cortical immunostaining for TLR4. Hematoxylin stain; original magnification, ×400. (C) Quantitative analysis of tubular TLR4 staining. Data represent means ± SD for groups of eight animals. *P<0.05 versus the corresponding nondiabetic animals.
