Table 2.

Physical and biochemical parameters of experimental animals (n=8 per group)

Parameter	TLR4+/+				TLR4−/−
	Sham		Unx		Sham		Unx
	Nondiabetic	Diabetic	Nondiabetic	Diabetic	Nondiabetic	Diabetic	Nondiabetic	Diabetic
Body weight (g)
baseline	22.0±0.8	23.7±1.2	23.2±0.8	23.6±1.8	23.9±2.2	23.8±1.3	23.6±2.5	22.4±0.9
12 weeks	30.9±2.4	25.5±1.5	29.7±1.7	24.9±1.9	29.2±2.1	25.9±1.5	28.1±1.9	24.8±2.8
Blood glucose (mM)
baseline	6.9±1.3	6.1±0.8	7.2±1.4	6.6±0.8	7.0±1.2	6.4±1.5	6.9±1.5	7.4±1.3
12 weeks	6.8±1.2	22.7±4.8a	6.6±1.3	23.1±3.5a	7.2±1.0	22.1±3.4a	6.8±0.8	22.4±6.6a
UACR (μg/mg)
baseline	40.5±5.7	35.6±16.5	27.1±9.1	33.7±29.4	34.5±11.2	34.1±10.9	26.6±9.2	43.2±11.3
12 weeks	38.8±12.6	122.8±40.7a	34.0±5.2	389.3±152.4a,b	41.7±8.6	66.2±19.6	35.8±9.3	86.0±29.4a,c
Scr (mg/dl)
baseline	0.14±0.05	0.16±0.05	0.17±0.05	0.13±0.03	0.15±0.06	0.16±0.08	0.17±0.09	0.16±0.09
12 weeks	0.17±0.03	0.15±0.07	0.17±0.09	0.32±0.11a,b	0.14±0.03	0.16±0.07	0.16±0.03	0.19±0.09c

Sham, sham operation; Scr, serum creatinine.

^aP<0.05 versus the corresponding nondiabetic group.

^bP<0.05 versus the corresponding sham-operated group.

^cP<0.05 versus the corresponding TLR4^+/+ group.