Table 4.
Treatment Group | Congenital Anomaly Outcome (n) | All Offspring (n) | Proportion With Anomalies (%) | Crude OR | 95% CI | OR* | 95% CI |
---|---|---|---|---|---|---|---|
Females | |||||||
Not treated with radiation | 38 | 1,021 | 3.7 | 1.0 | Referent | 1.0 | Referent |
Ovarian radiation dose, Gy | |||||||
0.01-0.99 | 44 | 1,332 | 3.3 | 0.89 | 0.57 to 1.40 | 0.87 | 0.55 to 1.38 |
1.00-2.50 | 6 | 196 | 3.1 | 0.83 | 0.35 to 1.99 | 0.80 | 0.33 to 1.92 |
2.50+ | 5 | 225 | 2.2 | 0.59 | 0.20 to 1.75 | 0.59 | 0.20 to 1.75 |
Ptrend | .52 | .53 | |||||
Males | |||||||
Not treated with radiation | 15 | 707 | 2.1 | 1.0 | Referent | 1.0 | Referent |
Testicular radiation dose, Gy | |||||||
0.01-0.09 | 10 | 677 | 1.5 | 0.70 | 0.31 to 1.58 | 0.71 | 0.31 to 1.63 |
0.10-0.50 | 6 | 317 | 1.9 | 0.91 | 0.35 to 2.42 | 0.88 | 0.33 to 2.36 |
0.50+ | 5 | 224 | 2.2 | 1.07 | 0.38 to 2.98 | 1.01 | 0.36 to 2.83 |
Ptrend | .99 | .90 |
Abbreviation: OR, odds ratio.
ORs adjusted for calendar year of birth and maternal age (for the female analyses) and for calendar year of birth and paternal age (for the male analyses).