Table 4.

ORs and 95% CIs for the Association Between Gonad-Specific Radiotherapy Doses and Risk of Congenital Anomalies in the Offspring of Female and Male Childhood Cancer Survivors

Treatment Group	Congenital Anomaly Outcome (n)	All Offspring (n)	Proportion With Anomalies (%)	Crude OR	95% CI	OR*	95% CI
Females
Not treated with radiation	38	1,021	3.7	1.0	Referent	1.0	Referent
Ovarian radiation dose, Gy
0.01-0.99	44	1,332	3.3	0.89	0.57 to 1.40	0.87	0.55 to 1.38
1.00-2.50	6	196	3.1	0.83	0.35 to 1.99	0.80	0.33 to 1.92
2.50+	5	225	2.2	0.59	0.20 to 1.75	0.59	0.20 to 1.75
Ptrend				.52		.53
Males
Not treated with radiation	15	707	2.1	1.0	Referent	1.0	Referent
Testicular radiation dose, Gy
0.01-0.09	10	677	1.5	0.70	0.31 to 1.58	0.71	0.31 to 1.63
0.10-0.50	6	317	1.9	0.91	0.35 to 2.42	0.88	0.33 to 2.36
0.50+	5	224	2.2	1.07	0.38 to 2.98	1.01	0.36 to 2.83
Ptrend				.99		.90

Abbreviation: OR, odds ratio.

^*ORs adjusted for calendar year of birth and maternal age (for the female analyses) and for calendar year of birth and paternal age (for the male analyses).