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Tumor samples with BRAF V600E mutations demonstrating colocalized cutaneous squamous cell tumors and melanoma. (A) Sample 3: hematoxylin and eosin (H+E) stain demonstrating classical keratoacanthoma histology, with an interspersed S100-positive melanocytic population. (B) Low-power and (C) high-power images of H+E stains from sample 39. AE1/AE3-positive cells (squamous cell carcinoma) are demonstrated immediately adjacent to S100-positive and melan-A–positive cells (melanoma).
