Table 3.
Minimum inhibitory concentrations of pantetheine analogues 1–15 to E. coli grown in different media and effect of additives.
| Media Compound # |
M9 | Tryptone | M9 + Pana | M9 + β-Alab |
|---|---|---|---|---|
| MIC (µM) | MIC (µM) | MIC (µM) | MIC (µM) | |
| 1 | 6 | 50 | 500 | 250 |
| 2 | >500 | >500 | ndc | nd |
| 3 | 4 | >500 | >500 | >500 |
| 4 | 500 | >500 | nd | nd |
| 5 | 7.5 | >500 | >500 | >500 |
| 6 | 15 | >500 | >500 | >500 |
| 7 | 500 | >500 | nd | nd |
| 8 | >500 | >500 | nd | nd |
| 9 | >500 | >500 | nd | nd |
| 10 | 3 | >500 | 250 | 125 |
| 11 | 1 | 500 | 500 | 250 |
| 12 | >500 | >500 | nd | nd |
| 13 | 500 | >500 | nd | nd |
| 14 | >500 | >500 | nd | nd |
| 15 | 500 | >500 | nd | nd |
a
Pan = addition of 1 mM pantothenate to growth medium.
b
β-Ala – addition of 1 mM β-alanine to growth medium.
c
nd = not determined.