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Mean S-COMT methylation levels with respect to the presumed COMT haplotype carrier status (A = twin cohort, B = adult controls). In both cohorts, no individuals homozygous for the HPS haplotype were found. All other haplotype combinations were ranked within an imaginary scale corresponding to the proposed phenotypical differences (high > average > low pain sensitive, according to [Nackley et al., 2006]).
