Table 1.
S-COMT methylation [% ± SD] with respect to COMT genotype in Blood DNA (twin cohort)
| Variant | CG1 | CG2b | mean | CG1 | CG2b | mean | CG1 | CG2b | mean | p-value |
|---|---|---|---|---|---|---|---|---|---|---|
| rs6269 | AA 44.8 ± 3.1 | 67.1 ± 3.1 | 56.0 ± 3.0 (n = 10) | AG 40.3 ± 3.0 | 62.1 ± 3.9 | 51.2 ± 3.4 (n = 24) | GG 30.6 ± 3.0 | 51.4 ± 3.0 | 41.0 ± 2.7 (n = 6) | < 0.01 |
| rs4633 | CC 33.2 ± 5.3 | 54.2 ± 5.8 | 43.7 ± 5.4 (n = 8) | CT 40.3 ± 3.2 | 62.0 ± 4.1 | 51.2 ± 3.5 (n = 22) | TT 44.8 ± 3.1 | 67.1 ± 3.1 | 56.0 ± 3.0 (n = 10) | < 0.01 |
| rs4680 | AA 44.8 ± 3.1 | 67.1 ± 3.1 | 56.0 ± 3.0 (n = 10) | AG 40.3 ± 3.2 | 62.0 ± 4.1 | 51.2 ± 3.5 (n = 22) | GG 33.2 ± 5.3 | 54.2 ± 5.8 | 43.7 ± 5.4 (n = 8) | < 0.01 |
Note that similar or equal methylation values across genotype groups for different SNPs result from a high (in the twin cohort almost complete) linkage disequilibrium between rs6269, rs4633, and rs4680. Please note that shown p-values were calculated using one-way ANOVAs, which do not take the interrelatedness of the observations into account.