Table 3.

S-COMT methylation [% ± SD] with respect to COMT genotype in Blood DNA (blood donors)

Variant	CG1	CG2b	mean	CG1	CG2b	mean	CG1	CG2b	mean	p-value
rs6269	AA 47.0 ± 4.6	60.1 ± 3.7	53.6 ± 3.5 (n = 26)	AG 42.2 ± 4.7	55.7 ± 5.1	49.0 ± 4.8 (n = 44)	GG 36.6 ± 4.6	51.4 ± 5.3	44.0 ± 4.8 (n = 23)	< 0.01
rs4680	AA 47.3 ± 4.2	60.3 ± 3.7	53.8 ± 3.4 (n = 33)	AG 40.8 ± 3.8	54.7 ± 4.5	47.8 ± 4.0 (n = 46)	GG 34.1 ± 4.1	49.1 ± 5.4	41.6 ± 4.5 (n = 14)	< 0.01

Note that due to the high linkage disequilibrium between rs6269, rs4633, and rs4680, in the replication cohort we assessed only rs6269 and rs4680, which are sufficient to differentiate between the 3 common activity haplotypes.