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. 2012 Feb 1;7(2):e30942. doi: 10.1371/journal.pone.0030942

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Martel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Protocol used for acquisition (left) and extinction (right) of cued fear conditioning. (B) Acquisition (left) and extinction (right) performances of GRPR WT and KO mice (11 WT and 12 KO). (C) Acquisition (left) and extinction (right) performances of stathmin WT and KO mice (16 WT and 11 KO). Acquisition performance is expressed as percentage of freezing during tone-shock pairings and extinction performance is expressed as percentage of freezing during 5 blocks (4 tones) for 4 days of extinction. Results are presented as mean ± SEM. R, renewal. *represents significant difference between groups during one block of a daily session; # represents significant difference between groups during the whole extinction phase.