Table 4.

Association of plasma lipoprotein(a) and genetic variants with cardiovascular disease incidence and mortality

	CHD		CVD		CVD death
	RR (95% CI)	P-value	RR (95% CI)	P-value	RR (95% CI)	P-value
Plasma Lp(a)a
Age adjusted
NHS	1.12 (0.98–1.26)	0.09	1.10 (0.98–1.23)	0.10	1.18 (0.95–1.47)	0.14
HPFS	1.04 (0.90–1.20)	0.63	1.04 (0.91–1.20)	0.56	1.15 (0.83–1.58)	0.40
Combinedb	1.08 (0.98–1.19)	0.12	1.08 (0.98–1.18)	0.10	1.17 (0.98–1.40)	0.09
Multivariate adjustedc
NHS	1.12 (0.98–1.28)	0.10	1.09 (0.97–1.23)	0.14	1.25 (0.99–1.57)	0.06
HPFS	0.97 (0.83–1.12)	0.65	0.99 (0.85–1.14)	0.85	1.09 (0.74–1.63)	0.66
Combinedb	1.05 (0.95–1.16)	0.35	1.05 (0.96–1.15)	0.32	1.21 (0.99–1.47)	0.06
Genetic variantsd
SNP rs10455872
NHS	0.95 (0.61–1.47)	0.81	0.99 (0.66–1.47)	0.94	0.76 (0.39–1.51)	0.43
HPFS	0.94 (0.61–1.46)	0.79	0.95 (0.63–1.45)	0.82	1.75 (0.98–3.13)	0.06
Combinedb	0.94 (0.69–1.28)	0.71	0.97 (0.73–1.30)	0.84	1.23 (0.79–1.92)	0.36
Genotype score
NHS	0.97 (0.88–1.07)	0.51	0.97 (0.89–1.06)	0.49	0.99 (0.87–1.14)	0.96
HPFS	0.98 (0.89–1.08)	0.67	1.00 (0.91–1.09)	0.96	0.95 (0.83–1.08)	0.42
Combinedb	0.98 (0.91–1.04)	0.48	0.98 (0.91–1.06)	0.69	0.97 (0.88–1.07)	0.53

^aThe RRs for plasma Lp(a) were estimated using Cox's regression.

^bResults were combined between women and men using inverse variance weights under fixed model, as there was no heterogeneity between women and men (all P for heterogeneity > 0.16).

^cMultivariate RR adjusted for age, fasting status, smoking, alcohol intake, physical activity, duration of diabetes, insulin use, aspirin use, cholesterol-lowering medication use, family history of MI, history of hypertension, BMI, LDL cholesterol, HDL cholesterol, triglycerides, A1C, and hormone replacement therapy use (women only).

^dData are odds ratios for the genetic association analysis after adjustment for age and BMI.