Table 1.
Comparison of Atherogenesis Phenotypes Among Mouse Strains with Various Genetic Modifications of Paraoxonase
| |
Diet |
|
|
||
|---|---|---|---|---|---|
| Mice model | Fat | CHO | Sodium cholate | Period | Plaque quantification |
| PON1 ko | 15.75% | 1.25% | 0.50% | 15 weeks | Cross-section |
| PON1 ko/ApoE ko | 42.00% | 0.15% | 0 | 16 weeks | En face |
| PON1 tg | 15.75% | 1.25% | 0.50% | 15 weeks | Cross-section |
| PON1 tg/ApoE ko | Regular chow | 28 weeks | Cross-section | ||
| PON2 ko | 15.80% | 1.25% | 0 | 15 weeks | Cross-section |
| PON3 tg | 15.75% | 1.25% | 0.50% | 15 weeks | Cross-section |
| PON3 tg/LDLR ko | 42.00% | 0.15% | 0 | 8 weeks | Cross-section |
| PON3 ad | Regular chow | 3 weeks | Cross-section | ||
| PC tg/ApoE ko | 10% | 1.25% | 0 | 10 or 16 weeks | En face and section |
CHO, cholesterol.