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. 2011 Oct 4;11(1):M111.007625. doi: 10.1074/mcp.M111.007625

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 4. — Regulatory network for PACAP-responsive genes. PACAP-regulated transcripts or proteins common to CHRF, PC12 and chromaffin primary sympathetic neuronal cells, ciliary ganglion neurons or PACAP knock out and wild-type mice (listed in Table II) were used as input for analysis of regulatory networks using IPA. The pathway showed is the highest-ranked network (score = 59). Abbreviations: Akt: Protein Kinase B; ATF4: activating transcription factor 4 (tax-responsive enhancer element B67); ATF4: activating transcription factor 4 (tax-responsive enhancer element B67); BTG2: BTG family, member 2; Caspase: caspase-1; Cbp: carboxypeptidase B1; Cdc2: cell cycle controller CDC2; Creb: Creb protein; DUSP1: dual specificity phosphatase 1; EGR1: early growth response 1; ELL2: elongation factor, RNA polymerase II, 2; ERRFI1: ERBB receptor feedback inhibitor 1; EZR: ezrin; FABP5: fatty acid binding protein 5 (psoriasis-associated); FOS: FBJ murine osteosarcoma viral oncogene homolog; FOSL1: FOS-like antigen 1; FOSL2: FOS-like antigen 2; FSH: follitropin; GADD45A: growth arrest and DNA-damage-inducible, alpha; GADD45G: growth arrest and DNA-damage-inducible, gamma; hCG: CG, Chorionic Gonadotropin; Hsp27: heat shock 27kDa protein; Hsp90: heat shock 90kDa protein; HSPB1: heat shock 27kDa protein 1; HSPB8: heat shock 22kDa protein 8; ID3: inhibitor of DNA binding 3, dominant negative helix-loop-helix protein; IER3: immediate early response 3; IL1: Interleukin 1; KLF4: Kruppel-like factor 4 (gut); LDL: Beta Lipoprotein, low density lipoprotein; LGALS3: lectin, galactoside-binding, soluble, 3; Lh: Luteinizing hormone; MAPKAPK2: mitogen-activated protein kinase-activated protein kinase 2; MCL1: myeloid cell leukemia sequence 1 (BCL2-related); Mek: mitogen-activated protein kinase kinase; NGF: nerve growth factor; NR4A1: nuclear receptor subfamily 4, group A, member 1; ODC1: ornithine decarboxylase 1; Pdgf: Platelet-Derived Growth Factor; PDGF BB: Pdgfb dimer; PI3K: P_i 3-kinase; Pkc(s): Protein kinase c; PLAT: plasminogen activator, tissue; PLK2: polo-like kinase 2 (Drosophila); PP2A: Protein Phosphatase Type2a; PVR: poliovirus receptor; RGS2: regulator of G-protein signaling 2, 24kDa; RHOB: ras homolog gene family, member B; Sapk: Stress-responsive protein kinase; STAT3: signal transducer and activator of transcription 3 (acute-phase response factor); TCR: T cell receptor, TCR protein; VGF: VGF nerve growth factor inducible.