Fig. 1.
A, Functional analysis of substrates from the three KAT families. Color represents the significance of functional term enrichment. A deep color means significant enrichment. Numbers on the color bar are equal to -log10P. p value is adjusted by the Benjamini method. B, Secondary structure analysis of substrates sites. All lysines: all the lysine sites in the human proteome. Acetylated lysines: all validated acetylated lysines including those without KAT information. CBP/p300: CBP/p300 family acetylated lysines. GCN5/PCAF: GCN5/PCAF family acetylated lysines. MYST: MYST family acetylated lysines.