Table I. Mean intensity of the monoisotopic (M+H+) ion peaks of inhibitor-sensitive and resistant peptides. This analysis was performed for the peptides in Figure 4.
MG-132 | Epoxomicin | |||||
---|---|---|---|---|---|---|
14N | 15N | 15N+Inh. | 14N | 15N | 15N+Inh. | |
Sensitive (n = 31) | 13461 | 11092 | 7026 (63%)c | 3001 | 2489 | 1644 (66%)c |
Resistant (n = 5) | 2818 | 2364a | 1657 (70%)c | 551 | 356b | 176 (49%)c |
Ratio | 4.8 | 4.7 | 4.2 | 5.4 | 7.0 | 9.3 |
a Range: 537 to 5030. As many as 20 inhibitor-sensitive peptides (64.5%) had higher intensity.
b Range: 56 to 602. As many as 17 inhibitor-sensitive peptides (54.8%) had higher intensity.
c Percent values are relative to peptides labeled in the absence of inhibitor (15N).