Table 1.

Regions reaching significance for the between-group analysis (PWS vs. OB) contrast between food and non-food categories.

Condition	Contrast	Region of Interest	Hemisphere	Voxels	x	y	z1	Z-score	Uncorrected p-value2	Voxel- level PFWE-corr3	Effect size of group difference4
Pre-meal	PWS > OB
		Nucleus accumbens	R	2	5	14	0	2.41	0.008	0.081	0.66
		Amygdala	R	11	23	−9	−5	2.21	0.014	0.191	0.45
	OB > PWS
		Hypothalamus	L	2	−6	−3	−11	2.15	0.016	0.197	0.41
		Hippocampus	L	4	−26	−26	−5	2.68	0.006	0.154	0.47
Post-meal	PWS > OB
		Hypothalamus	R	5	5	−9	−11	2.71	0.003	0.063	0.38
		Amygdala	R	14	14	0	−11	2.59	0.005	0.089	0.68
		Hippocampus	L	8	−12	−12	−13	2.72	0.003	0.093	0.68
	OB > PWS
		DLPFC	L	50	−44	34	19	2.75	0.003	0.039	0.95
		OFC	L	53	−27	33	−11	3.35	0.000	0.097	0.72

¹Coordinates are presented in Talairach space

²Voxel-wise Z-score significance level p<0.05 uncorrected for multiple comparisons within a hypothesized ROI; ROIs listed represent regions of significantly activated clusters within the a priori hypothesized ROI

³FWE rate (family-wise error rate) used for SVC (small volume correction): Voxel-level significance level (FWE-corrected within the search volume of interest)

⁴ES (Effect sizes) = standard deviations calculated as: differences between food versus non-food percent signal changes in PWS vs. OB; differences are divided by standard deviation of percent signal change value of the whole sample