Table 3.
Regions reaching significance for the between-group analysis (PWS vs. HWC) contrast between food and non-food categories.
| Condition | Contrast | Region of Interest | Hemisphere | Voxels | x | y | z1 | Z-score | Uncorrected p-value2 |
Voxel- level PFWE-corr3 |
|---|---|---|---|---|---|---|---|---|---|---|
| Pre-meal | PWS > HWC | |||||||||
| Hypothalamus | L | 10 | −6 | −9 | −3 | 3.41 | 0.000 | 0.011 | ||
| Amygdala | R L |
47 34 |
26 −20 |
−4 −9 |
−21 −13 |
3.38 3.16 |
0.000 0.001 |
0.026 0.047 |
||
| Hippocampus | L | 27 | −14 | −34 | 0 | 3.02 | 0.001 | 0.082 | ||
| mPFC | L | 33 | −9 | 44 | −15 | 2.89 | 0.002 | 0.151 | ||
| HWC > PWS | ||||||||||
| none | ||||||||||
| Post-meal | PWS > HWC | |||||||||
| Hypothalamus | R | 15 | 2 | −9 | −8 | 3.03 | 0.001 | 0.029 | ||
| Amygdala | R | 19 | 14 | −9 | −13 | 2.59 | 0.005 | 0.088 | ||
| Hippocampus | R | 43 | 17 | −15 | −16 | 3.56 | 0.000 | 0.031 | ||
| HWC > PWS | ||||||||||
| none | ||||||||||
1
Coordinates are presented in Talairach space
2
Voxel-wise Z-score significance level p<0.05 uncorrected for multiple comparisons within a hypothesized ROI; ROIs listed represent regions of significantly activated clusters within the a priori hypothesized ROI
3
FWE rate (family-wise error rate) used for SVC (small volume correction): Voxel-level significance level (FWE-corrected within the search volume of interest)