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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Invest Dermatol. 2011 Oct 27;132(3 0 1):695–702. doi: 10.1038/jid.2011.329

Figure 6. Male UVB-induced skin tumor-bearing mice exhibit higher percentages of splenic Gr-1+CD11b+ myeloid cells compared to females.

Figure 6

Male (n=15) and female mice (n=12) were exposed to UVB thrice weekly for 25 weeks to promote skin tumorigenesis. a, Flow cytometric analysis of Gr-1 and CD11b surface staining of splenocytes from skin tumor-bearing mice showed that males exhibited significantly higher percentages of splenic Gr-1+CD11b+ myeloid cells compared to females (p=0.005). Horizontal bars represent means. b, A multivariable linear regression model was constructed to determine if sex could predict splenic Gr-1+CD11b+ myeloid cell levels. After adjusting for total tumor area, male sex was a significant predictor of elevated splenic Gr-1+CD11b+ myeloid cells (p=0.0280) with an estimated 55% more splenic Gr-1+CD11b+ myeloid cells for a given tumor area.