Table 3.
IRS-2 Gly1057Asp polymorphism
| Control group#52 | PCOS group#48 | |||||
|---|---|---|---|---|---|---|
| Variable | Control Gly/Gly mean ± SD | Control X/Asp mean ± SD | Pvalue | PCOS Gly/Gly mean ± SD | PCOS X/Asp mean ± SD | Pvalue |
| Age | 30.3 ± 6.7 | 29.3 ± 6.2 | .239a | 25.2 ± 4.1 | 27.6 ± 5.9 | .131 |
| BMI | 26.7 ± 4.1 | 25.9 ± 4.0 | .448a | 25.5 ± 2.7 | 28.2 ± 6.2 | .077 |
| FBS | 88.5 ± 9.6 | 85.4 ± 9.4 | .243 | 89.7 ± 9.5 | 86.6 ± 11.7 | .243 |
| Post prandial BS | 95.9 ± 12.9 | 90.6 ± 12.0 | .131 | 94.7 ± 11.1 | 99.0 ± 14.9 | .131 |
| Fasting insulin | 10.2 ± 5.3 | 11.6 ± 4.7 | .301 | 12.1 ± 4.8 | 11.8 ± 6.0 | .301 |
| HOMA1-IR | 2.2 ± 1.2 | 2.4 ± 1.1 | .481 | 3.0 ± 1.9 | 2.5 ± 1.3 | .481 |
| Control group | PCOS group | |||||
| Family history | Positive | Negative | Pvalue | Positive | Negative | Pvalue |
| (Polymorphism frequency within group)%b | (1/1) 100 | (27/54) 52.9 | .350 | (9/13) 69.2 | (18/35) 51.4 | .269 |
| Hirsutism | Positive | Negative | Pvalue | Positive | Negative | Pvalue |
| (Polymorphism frequency within group)% | (1/6) 16.7 | (27/46) 58.7 | .052 | (14/26) 53.8 | (13/22) 59.1 | .715 |
| Insulin resistance | Positive | Negative | Pvalue | Positive | Negative | Pvalue |
| (Polymorphism frequency within group)% | (7/13) 53.8 | (21/39) 53.8 | 1.000 | (7/13) 53.8 | (20/35) 57.1 | .838 |
| Overweight and obesity | Positive | Negative | Pvalue | Positive | Negative | Pvalue |
| (Polymorphism frequency within group)% | (17/31) 54.8 | (11/21) 52.4 | .862 | (18/34) 52.9 | (9/14) 64.3 | .471 |
aTested with Mann–Whitney
bThe differences between total number of patients within groups are due to improper documentation