Table 4.
IRS-2 Gly1057Asp polymorphism in overweight/obese samples
| Overweight/obese control group | Overweight/obese PCOS group | |||||
|---|---|---|---|---|---|---|
| Variable | Control Gly/Gly mean ± SD | Control X/Asp mean ± SD | Pvalue | PCOS Gly/Gly mean ± SD | PCOS X/Asp mean ± SD | Pvalue |
| Age | 30.6 ± 5.9 | 29.9 ± 6.6 | .765 | 25.5 ± 4.2 | 28.1 ± 6.4 | .166 |
| BMI | 29.5 ± 2.8 | 28.4 ± 2.8 | .200a | 27.9 ± 3.9 | 31.1 ± 5.1 | .008a |
| FBS | 86.0 ± 11.0 | 83.8 ± 10.9 | .527 | 88.9 ± 10.4 | 86.7 ± 11.8 | .568 |
| 2hpp BS | 98.7 ± 12.1 | 87.1 ± 13.5 | .020 | 93.2 ± 11.9 | 99.7 ± 12.8 | .153 |
| Fasting insulin | 11.1 ± 5.0 | 12.9 ± 3.9 | .291 | 12.1 ± 4.8 | 11.0 ± 6.1 | .579 |
| HOMA1-IR | 2.4 ± 1.2 | 2.7 ± 1.0 | .477 | 2.6 ± 1.0 | 2.3 ± 1.4 | .557 |
| Overweight/obese control group | Overweight/obese PCOS group | |||||
| Family history | Positive | Negative | Pvalue | Positive | Negative | Pvalue |
| (Polymorphism frequency within group)%b | (0/0) – | (17/31) 54.8 | – | (7/9) 77.8 | (11/25) 44 | .082 |
| Hirsutism | Positive | Negative | Pvalue | Positive | Negative | Pvalue |
| (Polymorphism frequency within group)% | (0/3) 0 | (17/28) 60.7 | .081 | (11/20) 55 | (7/14) 50 | .774 |
| Insulin Resistance | Positive | Negative | Pvalue | Positive | Negative | Pvalue |
| (Polymorphism frequency within group)% | (5/9) 55.6 | (12/22) 54.5 | .959 | (4/8) 50 | (14/26) 53.8 | .849 |
aTested with Mann–Whitney
bThe differences between total number of patients within groups are due to improper documentation