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. Author manuscript; available in PMC: 2013 Jul 12.
Published in final edited form as: Oncogene. 2011 Oct 31;31(28):3322–3332. doi: 10.1038/onc.2011.494

Figure 1.

Figure 1

Loss of TGFBR1 and activation of PTEN/PI3K/Akt pathway in HNSCC samples. (a) TGFBR1 mRNA significantly reduced in HNSCC cell lines by qRT-PCR. Human oral keratinocytes (HOK) were used as normal control. (b) Western blot analysis demonstrates that p-Akt was overexpressed in most of the HNSCC cell lines. (c) Tissue array analysis revealed that TGFBR1, p-Smad2, and PTEN expression were reduced, while p-Akt was overexpressed in most human HNSCCs by IHC. The dotted lines delineate the adjacent epithelial compartment (magnification, 200X). Bar=100um.