Table 4.

Transmission of risk allele (A) for TNFα-308 promoter SNP (rs1800629) in neonatal lupus (NL) trio cohort

Transmission Disequilibrium Test
	Mothers with NL Child				Mothers with Cardiac NL Child				Caucasian Mothers with Cardiac NL Child
		Nontransmitted				Nontransmitted				Nontransmitted
	Allele	A	G		Allele	A	G		Allele	A	G
Transmitted	A	3	20	23	A	3	16	19	A	3	16	19
	G	3	24	27	G	2	21	23	G	2	21	23
		6	44	50		5	35	42		5	35	42
	OR=6.67 CI=(1.98–35.03)				OR=8.00 CI=(1.88–71.72)				OR=8.00 CI=(1.88–71.72)
	PTDT=3.93×10−4				PTDT=9.67×10−4				PTDT=9.67×10−4
Pedigree Disequilibrium Test
	Mothers with NL Child				Mothers with Cardiac NL Child				Caucasian Mothers with Cardiac NL Child
	Allele	Transmitted	Nontransmitted		Allele	Transmitted	Nontransmitted		Allele	Transmitted	Nontransmitted
	A	31	9.0		A	25	7.4		A	24	7.3
	G	51	72.0		G	43	60.6		G	40	56.7
		PMarginal=1.52×10−4				PMarginal=5.44×10−4				PMarginal=7.52×10−4
		Number of Complete trios		25	Number of Complete trios			21	Number of Complete trios			21
		Number of Pedigrees		43	Number of Pedigrees			35	Number of Pedigrees			32