Table 4.
Comparison of our results with those of other studies in the literature evaluating local recurrence in soft tissue sarcoma
| Study | Study period | Number of patients | Selection criteria | Margin categories | Local recurrence at 5 years | Conclusion |
|---|---|---|---|---|---|---|
| Novais et al. [18] (2010) | 1995–2008 | 248 | Extremity | + and ≤ 2 mm | 11.6% | > 2-mm margin suggested |
| Primary, deep, | > 2 mm | 2.4% | ||||
| Intermediate to high grade | > 2 cm | 0.0% | ||||
| No outside biopsy | ||||||
| No low grade | ||||||
| Gronchi et al. [8] (2010) | 1985–2005 | 997 | Adult | + | > 1-mm margin had low LR | |
| Extremity | < 1 mm | 26.0% | ||||
| Curative intent | > 1 mm | 10.0% | ||||
| Liu et al. [16] (2010) | 1997–2007 | 181 | Extremity | + or < 1 mm | 45% overall | High LR |
| Recommend >10-m margin | ||||||
| > 15 years old | 1–4 mm | |||||
| No LR | 5–9 mm | |||||
| 10–19 mm | ||||||
| 20–29 mm | ||||||
| > 30 mm | ||||||
| Kawaguchi et al. [10] (2004) | 837 | Bone and soft tissue sarcoma | + | 79% | High LR overall | |
| < 1 cm | 40% | Recommend 2-cm margin | ||||
| 1–4 cm | 11% | |||||
| 5 cm | 10% | |||||
| McKee et al. [17] (2004) | 1979–1998 | 111 | No abdominal or retroperitoneal | + | 42% | > 10-mm margin suggested for LR |
| 1–2 mm | 38% | |||||
| 3–9 mm | 31% | |||||
| No LR or mets | > 10 mm | 16% | ||||
| Baldini et al. [2] (1999) | 1970–1994 | 74 | Primary localized | < 1 cm | 8% | XRT not necessary for select patients |
| Trunk or extremity | ≥ 1 cm | 0% | ||||
| No XRT or chemo | ||||||
| Sadoski et al. [21] (1993) | 1974–1988 | 132 | All had preop XRT | + | 18% | ≤ 1-mm margins had low LR with preop XRT |
| Extremity | ≤ 1 mm | 6% | ||||
| Adult | > 1 mm | 3% | ||||
| Zagars et al. [26] (2003) | 1960–1999 | 1225 | All had XRT | + | 36% | + margins ↑ risk of LR |
| No mets at presentation | − | 12% | ||||
| Pisters et al. [19] (1996) | 1982–1994 | 1041 | Extremity | + or < 1 mm | 40% | + margins ↑ risk of LR |
| Localized | > 1 mm | 20% | ||||
| Dickinson et al. [3] (2006) | 1987–2002 | 279 | No LR | + | + and < 1 mm had higher rate of LR | > 1-mm margins adequate for local control |
| No Mets | < 1 mm | |||||
| 1–4 mm | ||||||
| 5–9 mm | ||||||
| 10–19 mm | ||||||
| > 20 mm | ||||||
| Kim et al. [14] (2010) | 2000–2006 | 56 | All with preop | + | 55.6% | ≥ 1-mm margin with preop XRT adequate for local control |
| XRT | + and < 1 mm | 33% | ||||
| No LR | > 1 mm | 0% | ||||
| Adults | Overall 11.5% | |||||
| Stojadinovic et al. [24] (2002) | 1982–2000 | 2084 | > 16 years old | + | 35% | + margins doubled risk of LR |
| Localized | − | 18% | ||||
| Kim et al. [15] (2008) | 1980–2003 | 150 | Extremity and trunk | + or < 10 mm | 24.5% | No difference in LR based on margin if XRT given but high LR overall |
| Postop XRT patients | > 10 mm | 21.4% | ||||
| No mets | ||||||
| Tanabe et al. [25] (1994) | 1970–1987 | 95 | Intermediate to high grade | + | 38% | + margins had ↑ LR despite preop XRT |
| Extremity | − | 9% | ||||
| Preop XRT | ||||||
| Al Yami et al. [1] (2010) | 1986–2003 | 58 | Extremity and trunk | Planned + microscopic | 10.3% | planned + microscopic margins have low LR rates |
| No chemo | ||||||
| Planned + margin patients | ||||||
| Current study (2011) | 2001–2007 | 117 | Adult Extremity | < 1 mm | 4.4% | No differences |
| No LR | 1–5 mm | 2.6% | Low LR even with narrow margins | |||
| No mets | > 5 mm | 3.8% |
LR = local recurrence; mets = metastatic lesions; XRT = radiation therapy; chemo = chemotherapy; preop = preoperative; postop = postoperative.