Table 2.

Brain regions with significantly decreased or increased rCBF in response to acute VNS (significance: t = 3.43, p < .005).

Brain Regions	Side	Voxels	t-Score	BA	Talairach Coordinates
					X	Y	Z
Decreased rCBF
Lateral orbital cortex	L	84	3.78	47,11	−40	44	−10
Lateral orbital cortex	R	193	3.80	47,11	40	48	−5
Inferior Temporal Gyrus	L	212	3.91	20	−62	−21	−29
Increased rCBF
Posterior Limb Internal Capsule/Medial putamen*	L	266	3.88	n/a	−21	−20	14
Rostral/Dorsal anterior cingulate**	R	253	3.86	24	8	17	26
Superior temporal gyrus	R	100	3.55	22	53	−43	13
Ventromedial cerebellum	L	63	3.65	n/a	−18	−83	−44
Ventrolateral cerebellum	L	116	3.65	n/a	−48	−53	−47

^*Region falls predominantly in white matter. This could represent increased rCBF to the white matter of the internal capsule; however, it more likely increased blood flow to the adjacent medial putamen.

^**also includes portions of corpus callosum