Table 3.
Multivariate analysis of clinical outcomes by HistoCheck DSS score quartile groups and treated as a continuous variable
Outcome | Group 1 DSS 1.04 – 2.84a |
Group 2 DSS >2.84 – 13.75 RR (95% CI) |
Group 3 DSS >13.75 – 19.39 RR (95% CI) |
Group 4 DSS >19.39 – 36.62 RR (95% CI) |
Overall P-value | DSS Continuous P-value |
---|---|---|---|---|---|---|
Acute GVHD II-IV | 1.00 | 1.06 (0.79 – 1.41) | 1.05 (0.79 – 1.39) | 1.16 (0.88 – 1.54) | 0.78 | 0.50 |
Chronic GVHD | 1.00 | 0.86 (0.61 – 1.21) | 0.82 (0.59 – 1.14) | 0.97 (0.69 – 1.37) | 0.61 | 0.89 |
Treatment-related mortality | 1.00 | 1.22 (0.91 – 1.63) | 1.13 (0.84 – 1.51) | 1.32 (0.98 – 1.77) | 0.29 | 0.58 |
Relapse | 1.00 | 1.47 (0.93 – 2.32) | 0.99 (0.61 – 1.60) | 1.44 (0.93 – 2.26) | 0.14 | 0.34 |
Overall survival | 1.00 | 1.25 (0.98 – 1.61) | 1.07 (0.83 – 1.38) | 1.28 (1.00 – 1.64) | 0.14 | 0.57 |
Disease-free survival | 1.00 | 1.30 (1.01 – 1.66) | 1.11 (0.86 – 1.42) | 1.35 (1.05 – 1.73) | 0.06 | 0.45 |
Neutrophil engraftmentb | 1.00 | 0.85 (0.41 – 1.75) | 0.63 (0.32 – 1.25) | 0.48 (0.25 – 0.95) 0.13 | 0.03 |
Reference group
Data reported as an odds ratio in favor of engraftment