Table 1. Characteristics of patients enrolled in the three GMALL study trials 05/93, 06/99 and 07/03 with the diagnosis of early T-ALL.
| ETP-ALL (n=57) (%) | Non-ETP early T-ALL (n=121) (%) | P | |
|---|---|---|---|
| Sex | |||
| Male | 47 (82.5) | 84 (69.4) | 0.07 |
| Female | 10 (17.5) | 37 (30.6) | |
| Age | |||
| 15–35 | 27 (47.4) | 68 (56.2) | 0.27 |
| 36–65 | 30 (52.6) | 53 (43.8) | |
| WBC count (n=163) | |||
| <30/nl | 32 (62.7) | 71 (63.4) | 0.94 |
| >30/nl | 19 (37.3) | 41 (36.6) | |
| Mediastinal mass (n=162) | |||
| No | 37 (72.5) | 59 (53.2) | 0.02 |
| Yes | 14 (27.5) | 52 (46.8) | |
| CNS involvement (n=150) | |||
| No | 42 (91.3) | 100 (96.2) | 0.22 |
| Yes | 4 (8.7) | 4 (3.8) | |
| Response to induction | |||
| CR | 42 (79.2) | 93 (82.3) | 0.65 |
| PR/failure | 5 (9.4) | 12 (11.7) | |
| Death in induction | 6 (11.3) | 8 (7.8) | |
Abbreviations: CNS, central nervous system; CR, complete remission; ETP-ALL, early T-cell precursors-acute lymphoblastic leukemia; PR, partial remission; T-ALL, acute T-lymphoblastic leukemia; WBC, white blood cell.
Comparison between ETP-ALL and early T-ALL with a non-ETP immunophenotype.