Table 2. Gene mutation status compared between (a) ETP-ALL and non-ETP T-ALL and (b) ETP-ALL and non-ETP early T-ALL.
| ETP-ALL (%) | Non-ETP T-ALL (%) | P | ETP-ALL (%) | Non-ETP early T-ALL (%) | P | ||
|---|---|---|---|---|---|---|---|
| (a) | (b) | ||||||
| FBXW7 (n=128) | FBXW7 (n=50) | ||||||
| wt | 14 (100) | 98 (86) | 0.13 | wt | 14 (100) | 27 (100) | — |
| mut | 0 (0) | 16 (14) | mut | 0 (0) | 0 (0) | ||
| NOTCH1 (n=142) | NOTCH1 (n=50) | ||||||
| wt | 13 (92.9) | 50 (39.1) | <0.001 | wt | 13 (92.9) | 16 (47.1) | 0.003 |
| mut | 1 (7.1) | 78 (60.9) | mut | 1 (7.1) | 18 (52.9) | ||
| FLT3 (ITD) (n=123) | FLT3 (ITD) (n=40) | ||||||
| wt | 14 (87.5) | 107 (100) | <0.001 | wt | 14 (75) | 24 (100) | 0.08 |
| mut | 2 (12.5) | 0 (0) | mut | 2 (25) | 0 (0) | ||
| FLT3 (D835) (n=116) | FLT3 (D835) (n=40) | ||||||
| wt | 12 (75) | 99 (99) | <0.001 | wt | 12 (75) | 23 (95.8) | 0.05 |
| mut | 4 (25) | 1 (1) | mut | 4 (25) | 1 (4.2) | ||
| WT1 (n=227) | WT1 (n=63) | ||||||
| wt | 12 (80) | 196 (92.5) | 0.09 | wt | 12 (80) | 42 (87.5) | 0.47 |
| mut | 3 (20) | 16 (7.5) | mut | 3 (20) | 6 (12.5) | ||
Abbreviations: ETP-ALL, early T-cell precursors-acute lymphoblastic leukemia; ITD, internal tandem duplications; mut, mutant; T-ALL, acute T-lymphoblastic leukemia; wt, wild type.
Non-ETP T-ALL includes all thymic, mature and early T-ALL with a non-ETP immunophenotype. Analysis was performed as far as sufficient material was available.